36 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 12/01/1979 | H | South Alabama | 10 | W | 75 | 73 | 1-0 | 0-0 | 16,613 | Louisville | Ky. | Freedom Hall | |||
| 12/05/1979 | H | Chattanooga | 14 | W | 87 | 63 | 2-0 | 0-0 | 13,266 | Louisville | Ky. | Freedom Hall | |||
| 12/08/1979 | A | Tennessee | 14 | W | 77 | 75 | 3-0 | 0-0 | 12,700 | Knoxville | Tenn. | Stokely Center | |||
| 12/13/1979 | H | Charlotte | 12 | W | 93 | 76 | 4-0 | 0-0 | 13,057 | Louisville | Ky. | Freedom Hall | 1979 Louisville Holiday Classic | ||
| 12/14/1979 | H | Western Kentucky | 12 | W | 96 | 74 | 5-0 | 0-0 | 14,012 | Louisville | Ky. | Freedom Hall | 1979 Louisville Holiday Classic | ||
| 12/19/1979 | H | 2 | Ohio State | 11 | W | 75 | 65 | 6-0 | 0-0 | 16,613 | Louisville | Ky. | Freedom Hall | ||
| 12/22/1979 | A | Utah | 11 | L | 69 | 71 | 6-1 | 0-0 | 11,060 | Salt Lake City | Utah | Sports and Special Events Center | |||
| 12/28/1979 | N | Princeton | 12 | W | 64 | 53 | 7-1 | 0-0 | 3,911 | Honolulu | Hawaii | Neal S. Blaisdell Arena | 1979 Rainbow Classic | ||
| 12/29/1979 | N | Illinois | 12 | L | 64 | 77 | 7-2 | 0-0 | 4,781 | Honolulu | Hawaii | Neal S. Blaisdell Arena | 1979 Rainbow Classic | ||
| 12/30/1979 | N | Nebraska | 12 | W | 65 | 58 | 8-2 | 0-0 | 5,633 | Honolulu | Hawaii | Neal S. Blaisdell Arena | 1979 Rainbow Classic | ||
| 01/03/1980 | H | Tulsa | 15 | W | 78 | 58 | 9-2 | 0-0 | 13,334 | Louisville | Ky. | Freedom Hall | |||
| 01/05/1980 | H | Kansas State | 15 | W | 85 | 73 | 10-2 | 0-0 | 16,613 | Louisville | Ky. | Freedom Hall | |||
| 01/08/1980 | H | Saint Louis | 11 | W | 94 | 65 | 11-2 | 1-0 | 14,285 | Louisville | Ky. | Freedom Hall | |||
| 01/12/1980 | A | Memphis | 11 | W | 69 | 48 | 12-2 | 2-0 | 10,899 | Memphis | Tenn. | Mid-South Coliseum | |||
| 01/19/1980 | A | Tulane | 7 | W | 76 | 59 | 13-2 | 3-0 | 3,125 | New Orleans | La. | Tulane Gym | |||
| 01/22/1980 | H | Marquette | 7 | W | 76 | 63 | 14-2 | 3-0 | 16,613 | Louisville | Ky. | Freedom Hall | |||
| 01/25/1980 | A | Saint Louis | 7 | W | 99 | 74 | 15-2 | 4-0 | 7,345 | St. Louis | Mo. | Checkerdome | |||
| 01/27/1980 | H | Florida State | 7 | W | 79 | 73 | 16-2 | 5-0 | 14,495 | Louisville | Ky. | Freedom Hall | |||
| 01/31/1980 | H | Tulane | 7 | W | 64 | 60 | 17-2 | 6-0 | 13,262 | Louisville | Ky. | Freedom Hall | |||
| 02/03/1980 | A | 9 | St. John's | 7 | W | 76 | 71 | 18-2 | 6-0 | 6,168 | Queens | N.Y. | Alumni Hall | ||
| 02/04/1980 | H | Memphis | 3 | W | 88 | 60 | 19-2 | 7-0 | 15,536 | Louisville | Ky. | Freedom Hall | |||
| 02/06/1980 | H | Cincinnati | 3 | W | 88 | 73 | 20-2 | 8-0 | 16,613 | Louisville | Ky. | Freedom Hall | |||
| 02/09/1980 | A | Providence | 3 | W | 79 | 73 | 21-2 | 8-0 | 8,615 | Providence | R.I. | Providence Civic Center | |||
| 02/11/1980 | A | Virginia Tech | 3 | W | 56 | 54 | OT | 22-2 | 9-0 | 10,000 | Blacksburg | Va. | Cassell Coliseum | ||
| 02/14/1980 | A | West Virginia | 3 | W | 90 | 78 | 23-2 | 9-0 | 10,136 | Morgantown | W.V. | WVU Coliseum | |||
| 02/16/1980 | A | Cincinnati | 3 | W | 61 | 57 | 24-2 | 10-0 | 16,018 | Cincinnati | Ohio | Riverfront Coliseum | |||
| 02/18/1980 | H | Virginia Tech | 2 | W | 77 | 72 | 25-2 | 11-0 | 16,613 | Louisville | Ky. | Freedom Hall | |||
| 02/21/1980 | N | Iona | 2 | L | 60 | 77 | 25-3 | 11-0 | 18,592 | New York | N.Y. | Madison Square Garden IV | |||
| 02/24/1980 | A | Florida State | 2 | W | 83 | 75 | 26-3 | 12-0 | 3,700 | Tallahassee | Fla. | Tully Gymnasium | |||
| 02/29/1980 | H | Memphis | 4 | W | 84 | 65 | 27-3 | 12-0 | 14,155 | Louisville | Ky. | Freedom Hall | 1980 Metro Tournament Seminfinal | ||
| 03/01/1980 | H | Florida State | 4 | W | 81 | 72 | 28-3 | 12-0 | 11,668 | Louisville | Ky. | Freedom Hall | 1980 Metro Tournament Final | ||
| 03/08/1980 | N | Kansas State | 2 | W | 71 | 69 | OT | 29-3 | 12-0 | 14,458 | Lincoln | Neb. | Bob Devaney Sports Center | 1980 NCAA Tournament Midwest Regional Second Round | |
| 03/14/1980 | N | Texas A&M | 2 | W | 66 | 55 | OT | 30-3 | 12-0 | 15,400 | Houston | Texas | The Summit | 1980 NCAA Tournament Midwest Regional Semifinal | |
| 03/16/1980 | N | 3 | Louisiana State | 2 | W | 86 | 66 | 31-3 | 12-0 | 15,400 | Houston | Texas | The Summit | 1980 NCAA Tournament Midwest Regional Final | |
| 03/22/1980 | N | Iowa | 2 | W | 80 | 72 | 32-3 | 12-0 | 16,637 | Indianapolis | Ind. | Market Square Arena | 1980 NCAA Tournament Semifinal | ||
| 03/24/1980 | N | UCLA | 2 | W | 59 | 54 | 33-3 | 12-0 | 16,637 | Indianapolis | Ind. | Market Square Arena | 1980 NCAA Tournament Final |