30 games, 2 exhibitions
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/04/1991 | H | Latvia (Exhibition) | 25 | W | 104 | 74 | 18,146 | Louisville | Ky. | Freedom Hall | |||||
| 11/23/1991 | H | Howard | 25 | W | 102 | 73 | 1-0 | 0-0 | 19,315 | Louisville | Ky. | Freedom Hall | |||
| 12/05/1991 | A | Notre Dame | W | 84 | 81 | 2-0 | 0-0 | 8,467 | South Bend | Ind. | Joyce Athletic and Convocation Center | ||||
| 12/07/1991 | H | Athletes in Action (Exhibition) | W | 99 | 86 | 18,044 | Louisville | Ky. | Freedom Hall | ||||||
| 12/10/1991 | H | Maryland | W | 96 | 79 | 3-0 | 0-0 | 19,357 | Louisville | Ky. | Freedom Hall | ||||
| 12/14/1991 | H | George Mason | W | 85 | 66 | 4-0 | 0-0 | 19,272 | Louisville | Ky. | Freedom Hall | ||||
| 12/19/1991 | H | Morehead State | 25 | W | 90 | 76 | 5-0 | 0-0 | 19,333 | Louisville | Ky. | Freedom Hall | |||
| 12/21/1991 | A | Louisiana State | 25 | W | 93 | 92 | 6-0 | 0-0 | 12,978 | Baton Rouge | La. | Maravich Assembly Center | |||
| 12/28/1991 | A | 17 | Kentucky | 21 | L | 89 | 103 | 6-1 | 0-0 | 24,295 | Lexington | Ky. | Rupp Arena | ||
| 01/02/1992 | H | Houston | 24 | W | 60 | 56 | 7-1 | 0-0 | 19,247 | Louisville | Ky. | Freedom Hall | |||
| 01/04/1992 | H | Tulane | 24 | L | 83 | 87 | OT | 7-2 | 0-1 | 19,348 | Louisville | Ky. | Freedom Hall | ||
| 01/09/1992 | A | Virginia Commonwealth | L | 57 | 66 | 7-3 | 0-2 | 7,459 | Richmond | Va. | Richmond Coliseum | ||||
| 01/11/1992 | A | 4 | Kansas | W | 85 | 78 | 8-3 | 0-2 | 15,800 | Lawrence | Kan. | Allen Fieldhouse | |||
| 01/16/1992 | H | South Florida | 25 | W | 60 | 47 | 9-3 | 1-2 | 19,242 | Louisville | Ky. | Freedom Hall | |||
| 01/18/1992 | H | Wyoming | 25 | W | 68 | 60 | 10-3 | 1-2 | 19,315 | Louisville | Ky. | Freedom Hall | |||
| 01/23/1992 | H | Southern Mississippi | 20 | W | 88 | 74 | 11-3 | 2-2 | 19,329 | Louisville | Ky. | Freedom Hall | |||
| 01/25/1992 | H | 18 | Georgia Tech | 20 | L | 65 | 73 | 11-4 | 2-2 | 19,432 | Louisville | Ky. | Freedom Hall | ||
| 01/28/1992 | A | Virginia Tech | 24 | W | 78 | 68 | 12-4 | 3-2 | 6,738 | Blacksburg | Va. | Cassell Coliseum | |||
| 01/30/1992 | A | 17 | Charlotte | 24 | L | 68 | 77 | OT | 12-5 | 3-3 | 11,080 | Charlotte | N.C. | Charlotte Coliseum | |
| 02/02/1992 | H | 2 | UCLA | 24 | L | 64 | 78 | 12-6 | 3-3 | 19,466 | Louisville | Ky. | Freedom Hall | ||
| 02/06/1992 | H | 20 | Charlotte | W | 73 | 63 | 13-6 | 4-3 | 19,384 | Louisville | Ky. | Freedom Hall | |||
| 02/08/1992 | N | Xavier | W | 86 | 73 | 14-6 | 4-3 | 13,266 | Cincinnati | Ohio | Riverfront Coliseum | ||||
| 02/13/1992 | A | South Florida | L | 66 | 69 | 14-7 | 4-4 | 10,047 | Tampa | Fla. | USF Sun Dome | ||||
| 02/16/1992 | A | DePaul | L | 81 | 84 | 14-8 | 4-4 | 14,946 | Rosemont | Ill. | Rosemont Horizon | ||||
| 02/18/1992 | H | Virginia Commonwealth | W | 89 | 71 | 15-8 | 5-4 | 19,393 | Louisville | Ky. | Freedom Hall | ||||
| 02/22/1992 | A | Arizona State | W | 63 | 62 | OT | 16-8 | 5-4 | 10,031 | Tempe | Ariz. | University Activity Center | |||
| 02/27/1992 | A | 15 | Tulane | W | 87 | 72 | 17-8 | 6-4 | 3,691 | New Orleans | La. | Fogelman Arena | |||
| 02/29/1992 | A | Southern Mississippi | L | 70 | 82 | 17-9 | 6-5 | 6,337 | Hattiesburg | Miss. | Reed Green Coliseum | ||||
| 03/07/1992 | H | Virginia Tech | W | 79 | 59 | 18-9 | 7-5 | 19,386 | Louisville | Ky. | Freedom Hall | ||||
| 03/13/1992 | H | Virginia Commonwealth | L | 65 | 74 | 18-10 | 7-5 | 15,992 | Louisville | Ky. | Freedom Hall | 1992 Metro Tournament Quarterfinal | |||
| 03/20/1992 | N | Wake Forest | W | 81 | 58 | 19-10 | 7-5 | 7,639 | Tempe | Ariz. | University Activity Center | 1992 NCAA Tournament West Regional First Round | |||
| 03/22/1992 | N | 4 | UCLA | L | 69 | 85 | 19-11 | 7-5 | 10,125 | Tempe | Ariz. | University Activity Center | 1992 NCAA Tournament West Regional Second Round |