36 games, 2 exhibitions
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10/29/2007 | H | Carleton (Exhibition) | W | 82 | 49 | 17,244 | Louisville | Ky. | Freedom Hall | ||||||
| 10/31/2007 | H | Georgetown College (Exhibition) | W | 93 | 66 | 15,837 | Louisville | Ky. | Freedom Hall | ||||||
| 11/17/2007 | H | Hartford | 6 | W | 104 | 69 | 1-0 | 0-0 | 19,147 | Louisville | Ky. | Freedom Hall | 2007 Las Vegas Invitational | ||
| 11/18/2007 | H | Jackson State | 6 | W | 84 | 53 | 2-0 | 0-0 | 19,121 | Louisville | Ky. | Freedom Hall | 2007 Las Vegas Invitational | ||
| 11/21/2007 | A | Nevada-Las Vegas | 6 | W | 68 | 48 | 3-0 | 0-0 | 14,133 | Las Vegas | Nev. | Thomas & Mack Center | |||
| 11/23/2007 | N | Brigham Young | 6 | L | 76 | 78 | 3-1 | 0-0 | 4,590 | Las Vegas | Nev. | Orleans Arena | 2007 Las Vegas Invitational | ||
| 11/24/2007 | N | Old Dominion | 6 | W | 64 | 53 | 4-1 | 0-0 | 5,500 | Las Vegas | Nev. | Orleans Arena | 2007 Las Vegas Invitational | ||
| 12/01/2007 | H | Miami, Ohio | 12 | W | 47 | 44 | 5-1 | 0-0 | 19,427 | Louisville | Ky. | Freedom Hall | |||
| 12/08/2007 | H | Dayton | 14 | L | 65 | 70 | 5-2 | 0-0 | 19,128 | Louisville | Ky. | Freedom Hall | |||
| 12/15/2007 | N | Purdue | 22 | L | 59 | 67 | 5-3 | 0-0 | 17,170 | Indianapolis | Ind. | Conseco Fieldhouse | 2007 John Wooden Tradition | ||
| 12/18/2007 | H | Marshall | W | 85 | 75 | 6-3 | 0-0 | 19,036 | Louisville | Ky. | Freedom Hall | ||||
| 12/22/2007 | H | New Mexico State | W | 70 | 65 | 7-3 | 0-0 | 19,021 | Louisville | Ky. | Freedom Hall | 2007 Billy Minardi Classic | |||
| 12/26/2007 | H | Morehead State | W | 73 | 49 | 8-3 | 0-0 | 19,366 | Louisville | Ky. | Freedom Hall | ||||
| 12/29/2007 | H | Iona | W | 67 | 36 | 9-3 | 0-0 | 19,118 | Louisville | Ky. | Freedom Hall | ||||
| 01/01/2008 | H | Cincinnati | L | 57 | 58 | 9-4 | 0-1 | 19,488 | Louisville | Ky. | Freedom Hall | ||||
| 01/05/2008 | A | Kentucky | W | 89 | 75 | 10-4 | 0-1 | 24,386 | Lexington | Ky. | Rupp Arena | ||||
| 01/10/2008 | H | West Virginia | W | 63 | 54 | 11-4 | 1-1 | 19,764 | Louisville | Ky. | Freedom Hall | ||||
| 01/13/2008 | A | Rutgers | W | 64 | 49 | 12-4 | 2-1 | 5,879 | Piscataway | N.J. | Louis Brown Athletic Center | ||||
| 01/17/2008 | H | 13 | Marquette | W | 71 | 51 | 13-4 | 3-1 | 19,834 | Louisville | Ky. | Freedom Hall | |||
| 01/19/2008 | A | Seton Hall | L | 82 | 92 | 13-5 | 3-2 | 9,800 | Newark | N.J. | Prudential Center | ||||
| 01/23/2008 | A | South Florida | W | 80 | 60 | 14-5 | 4-2 | 4,781 | Tampa | Fla. | USF Sun Dome | ||||
| 01/26/2008 | H | St. John's | W | 67 | 57 | 15-5 | 5-2 | 19,462 | Louisville | Ky. | Freedom Hall | ||||
| 01/28/2008 | A | Connecticut | L | 67 | 69 | 15-6 | 5-3 | 15,120 | Hartford | Conn. | XL Center | ||||
| 02/02/2008 | H | Rutgers | W | 87 | 50 | 16-6 | 6-3 | 19,397 | Louisville | Ky. | Freedom Hall | ||||
| 02/04/2008 | A | 16 | Marquette | W | 71 | 57 | 17-6 | 7-3 | 17,736 | Milwaukee | Wisc. | Bradley Center | |||
| 02/09/2008 | H | 6 | Georgetown | W | 59 | 51 | 18-6 | 8-3 | 20,083 | Louisville | Ky. | Freedom Hall | |||
| 02/12/2008 | A | DePaul | 23 | W | 88 | 68 | 19-6 | 9-3 | 9,828 | Rosemont | Ill. | Allstate Arena | |||
| 02/16/2008 | A | Providence | 23 | W | 80 | 72 | 20-6 | 10-3 | 12,500 | Providence | R.I. | Dunkin' Donuts Center | |||
| 02/18/2008 | H | Syracuse | 18 | W | 61 | 50 | 21-6 | 11-3 | 19,868 | Louisville | Ky. | Freedom Hall | |||
| 02/24/2008 | A | Pittsburgh | 18 | W | 75 | 73 | 22-6 | 12-3 | 12,508 | Pittsburgh | Pa. | Petersen Events Center | |||
| 02/28/2008 | H | 17 | Notre Dame | 13 | W | 90 | 85 | 23-6 | 13-3 | 19,881 | Louisville | Ky. | Freedom Hall | ||
| 03/02/2008 | H | Villanova | 13 | W | 68 | 54 | 24-6 | 14-3 | 20,043 | Louisville | Ky. | Freedom Hall | |||
| 03/08/2008 | A | 11 | Georgetown | 12 | L | 52 | 55 | 24-7 | 14-4 | 19,116 | Washington | D.C. | Verizon Center | ||
| 03/13/2008 | N | Pittsburgh | 13 | L | 69 | 76 | OT | 24-8 | 14-4 | 19,562 | New York | N.Y. | Madison Square Garden IV | 2008 Big East Tournament Quarterfinal | |
| 03/21/2008 | N | Boise State | 13 | W | 79 | 61 | 25-8 | 14-4 | 14,315 | Birmingham | Ala. | BJCC Arena | 2008 NCAA Tournament East Regional First Round | ||
| 03/23/2008 | N | Oklahoma | 13 | W | 78 | 48 | 26-8 | 14-4 | 14,606 | Birmingham | Ala. | BJCC Arena | 2008 NCAA Tournament East Regional Second Round | ||
| 03/27/2008 | N | 5 | Tennessee | 13 | W | 79 | 60 | 27-8 | 14-4 | 19,092 | Charlotte | N.C. | Charlotte Bobcats Arena | 2008 NCAA Tournament East Regional Semifinal | |
| 03/29/2008 | N | 1 | North Carolina | 13 | L | 73 | 83 | 27-9 | 14-4 | 19,092 | Charlotte | N.C. | Charlotte Bobcats Arena | 2008 NCAA Tournament East Regional Final |