34 games, 2 exhibitions
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/03/2016 | H | Kentucky Wesleyan (Exhibition) | 13 | W | 109 | 71 | 15,836 | Louisville | Ky. | KFC Yum! Center | |||||
| 11/07/2016 | H | Bellarmine (Exhibition) | 13 | W | 81 | 60 | 16,437 | Louisville | Ky. | KFC Yum! Center | |||||
| 11/11/2016 | H | Evansville | 13 | W | 78 | 47 | 1-0 | 0-0 | 21,129 | Louisville | Ky. | KFC Yum! Center | |||
| 11/14/2016 | H | William & Mary | 12 | W | 91 | 58 | 2-0 | 0-0 | 19,314 | Louisville | Ky. | KFC Yum! Center | |||
| 11/17/2016 | H | Long Beach State | 12 | W | 88 | 56 | 3-0 | 0-0 | 14,337 | Louisville | Ky. | KFC Yum! Center | 2016 Battle 4 Atlantis | ||
| 11/23/2016 | N | Old Dominion | 10 | W | 68 | 62 | OT | 4-0 | 0-0 | 1,601 | Paradise Island | Bahamas | Imperial Arena | 2016 Battle 4 Atlantis | |
| 11/24/2016 | N | Wichita State | 10 | W | 62 | 52 | 5-0 | 0-0 | 1,604 | Paradise Island | Bahamas | Imperial Arena | 2016 Battle 4 Atlantis | ||
| 11/25/2016 | N | 20 | Baylor | 10 | L | 63 | 66 | 5-1 | 0-0 | 1,655 | Paradise Island | Bahamas | Imperial Arena | 2016 Battle 4 Atlantis | |
| 11/30/2016 | H | 15 | Purdue | 14 | W | 71 | 64 | 6-1 | 0-0 | 21,841 | Louisville | Ky. | KFC Yum! Center | 2016 ACC-Big Ten Challenge | |
| 12/03/2016 | A | Grand Canyon | 14 | W | 79 | 70 | 7-1 | 0-0 | 7,493 | Phoenix | Ariz. | GCU Arena | |||
| 12/07/2016 | H | Southern Illinois | 11 | W | 74 | 51 | 8-1 | 0-0 | 18,894 | Louisville | Ky. | KFC Yum! Center | |||
| 12/10/2016 | H | Texas Southern | 11 | W | 102 | 71 | 9-1 | 0-0 | 18,152 | Louisville | Ky. | KFC Yum! Center | |||
| 12/17/2016 | H | Eastern Kentucky | 11 | W | 87 | 56 | 10-1 | 0-0 | 20,889 | Louisville | Ky. | KFC Yum! Center | 2016 Billy Minardi Classic | ||
| 12/21/2016 | H | 6 | Kentucky | 10 | W | 73 | 70 | 11-1 | 0-0 | 22,783 | Louisville | Ky. | KFC Yum! Center | ||
| 12/28/2016 | H | 12 | Virginia | 6 | L | 53 | 61 | 11-2 | 0-1 | 21,676 | Louisville | Ky. | KFC Yum! Center | ||
| 12/31/2016 | N | 16 | Indiana | 6 | W | 77 | 62 | 12-2 | 0-1 | 18,824 | Indianapolis | Ind. | Bankers Life Fieldhouse | 2016 Countdown Classic | |
| 01/04/2017 | A | 23 | Notre Dame | 9 | L | 70 | 77 | 12-3 | 0-2 | 8,420 | South Bend | Ind. | Purcell Pavillion at Joyce Center | ||
| 01/07/2017 | A | Georgia Tech | 9 | W | 65 | 50 | 13-3 | 1-2 | 6,160 | Atlanta | Ga. | McCamish Pavilion | |||
| 01/11/2017 | H | Pittsburgh | 14 | W | 85 | 80 | 14-3 | 2-2 | 21,558 | Louisville | Ky. | KFC Yum! Center | |||
| 01/14/2017 | H | 7 | Duke | 14 | W | 78 | 69 | 15-3 | 3-2 | 22,686 | Louisville | Ky. | KFC Yum! Center | ||
| 01/19/2017 | H | Clemson | 12 | W | 92 | 60 | 16-3 | 4-2 | 21,436 | Louisville | Ky. | KFC Yum! Center | |||
| 01/21/2017 | A | 10 | Florida State | 12 | L | 68 | 73 | 16-4 | 4-3 | 11,675 | Tallahassee | Fla. | Donald L. Tucker Civic Center | ||
| 01/24/2017 | A | Pittsburgh | 13 | W | 106 | 51 | 17-4 | 5-3 | 8,971 | Pittsburgh | Pa. | Petersen Events Center | |||
| 01/29/2017 | H | North Carolina State | 13 | W | 85 | 60 | 18-4 | 6-3 | 21,650 | Louisville | Ky. | KFC Yum! Center | |||
| 02/04/2017 | A | Boston College | 6 | W | 90 | 67 | 19-4 | 7-3 | 7,047 | Chestnut Hill | Mass. | Conte Forum | |||
| 02/06/2017 | A | 12 | Virginia | 4 | L | 55 | 71 | 19-5 | 7-4 | 14,623 | Charlottesville | Va. | John Paul Jones Arena | ||
| 02/11/2017 | H | Miami, Fla. | 4 | W | 71 | 66 | 20-5 | 8-4 | 21,427 | Louisville | Ky. | KFC Yum! Center | |||
| 02/13/2017 | A | Syracuse | 8 | W | 76 | 72 | OT | 21-5 | 9-4 | 21,650 | Syracuse | N.Y. | Carrier Dome | ||
| 02/18/2017 | H | Virginia Tech | 8 | W | 94 | 90 | 22-5 | 10-4 | 21,524 | Louisville | Ky. | KFC Yum! Center | |||
| 02/22/2017 | A | 8 | North Carolina | 7 | L | 63 | 74 | 22-6 | 10-5 | 21,269 | Chapel Hill | N.C. | Dean E. Smith Center | ||
| 02/26/2017 | H | Syracuse | 7 | W | 88 | 68 | 23-6 | 11-5 | 22,482 | Louisville | Ky. | KFC Yum! Center | |||
| 03/01/2017 | A | Wake Forest | 8 | L | 81 | 88 | 23-7 | 11-6 | 11,488 | Winston-Salem | N.C. | Lawrence Joel Veterans Memorial Coliseum | |||
| 03/04/2017 | H | 19 | Notre Dame | 8 | W | 71 | 64 | 24-7 | 12-6 | 22,612 | Louisville | Ky. | KFC Yum! Center | ||
| 03/09/2017 | N | 14 | Duke | 10 | L | 77 | 81 | 24-8 | 12-6 | 17,732 | Brooklyn | N.Y. | Barclays Center | 2017 New York Life ACC Tournament Quarterfinal | |
| 03/17/2017 | N | Jacksonville State | 10 | W | 78 | 63 | 25-8 | 12-6 | 18,255 | Indianapolis | Ind. | Bankers Life Fieldhouse | 2017 NCAA Tournament Midwest Regional First Round | ||
| 03/19/2017 | N | 23 | Michigan | 10 | L | 69 | 73 | 25-9 | 12-6 | 18,293 | Indianapolis | Ind. | Bankers Life Fieldhouse | 2017 NCAA Tournament Midwest Regional Second Round |